Donald L. Lappé, M.D.

Clinical Interests:
Clinical cardiology
Advanced cardiology imaging

Research Interests:
CV outcomes
Lipids

Society Memberships:
American College of Cardiology - Fellow
American Heart Association

Pertinent Publications:

1. JD Graber, CR Conti, DL Lappé, RS Ross: Effect of pacing-induced tachycardia and myocardial ischemia on ventricular pressure-velocity relationships in man. Circulation 46:74083, 1972.
2. MD Stearn, DL Lappé, PD Bowen, JB Chimosky, GA Hollaway, H. Keiser, Jr., RL Bowman: Continuous measurement of tissue blood flow by laser Doppler spectroscopy. AM J Physiol 232:H441-448, 1977.
3. DL Lappé, BH Bulkley, JL Weiss: Two-dimensional echocardiographic diagnosis of left-atrial myxoma. Chest 74:55-56, 1978.
4. MD Ezokowitz, PO Alderson, BH Bulkley, PN Dwyer, L Watkins, DL Lappé, HL Green, LC Becker: Isolated drainage of superior vena cava into the left atrium in a 52-year-old man. Circulation 58:751-756, 1978.
5. JA Brinker, JL Weiss, DL Lappé, JL Rabson, WR Summer, S Permutt, ML Weisfeldt: Leftward septal displacement during right ventricular loading in man. Circulation 61:620-633, 1980.
6. DL Lappé, EG Lakatta: Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle. Science 207:1369-1371, 1980.
7. DL Lappé, EG Lakatta: Diastolic scattered light fluctuation, resting force and twitch force in mammalian cardiac muscle. J Physiology (London): 315, 1981.
8. DL Lappé, SK Kruegar: Right to left shunt through patent foramen ovale complicating right ventricular infarction. Chest 94:1100-1101, 1988.
9. Wagoner, LE, Taylor DO, Olsen, SL, Bristow MR, O’Connell, JB, Hammond, EH, DL Lappé , Renlund, DL: Cyclophosphamide in cardiac transplant recipients with frequent rejection: a six-year retrospective review. Clin Transplant 1996 Oct; 10(5): 437-443.
10. Wagoner LE, Olsen SL, Bristow MR, O”Connell JB, Taylor DO, DL Lappé, Renlund DG: Cyclophosphamide as an alternative to azathiprine in cardiac transplant recipients with suspected azathiprine-induced hepatotoxicity. Transplant. 1993 Dec: 56(6): 1415-1418.
11. Duffin DC, Muhlestein JB, Allison SB, Horne BD, Fowles RE, Sorensen SG, Revenaugh JR, Bair TL, Lappé DL. Femoral vascular hemostasis after percutaneous coronary procedures: patient satisfaction and outcomes for manual compression and two vascular closure devices. J Invasive Cardiol 2001;13:354-362.
12. Bunch TJ, Muhlestein JB, Bair TL, Horne BD, Jackson JD, Li Q, Lappé DL. Statins Improve Survival but not Clinical Restenosis: A Study of 2,902 Patients Undergoing Coronary Stent Deployment. Am J Cardiol 2002;90:299-302.
13. Jones HU, Muhlestein JB, Jones KW, Bair TL, Lavasani F, Sohrevardi M, Horne BD, Doty D, Lappé DL. Pre-operative use of enoxaparin compared to unfractionated heparin increases the incidence of re-exploration for post-operative bleeding after open heart surgery in patients who present with an acute coronary syndrome. Circulation 2002;106 [suppl I]:I-19-I-22.
14. Horne BD, Muhlestein JB, Lappé DL, Renlund DG, Bair TL, Bunch TJ, Anderson JL. Less affluent area of residence and lesser-insured status predict an increased risk of death or myocardial infarction after angiographic diagnosis of coronary disease. Ann Epidemiol 2004;14:143-150.
15. Anderson JL, Horne BD, Jones HU, Reyna SP, Carlquist JF, Bair TL, Pearson RR, Lappé DL, Muhlestein JB. Which features of the metabolic syndrome predict the prevalence and clinical outcomes of angiographic coronary artery disease? Cardiology 2004;101:185-193.
16. Lappé JM, Muhlestein JB, Lappé DL, Badger RS, Bair TL, Brockman R, French TK, Hofmann LC, Horne BD, Kralick-Goldberg S, Nicponski N, Orton JA, Pearson RR, Renlund DG, Rimmasch H, Roberts C, Anderson JL. Improvements in long-term clinical outcome of cardiovascular patients by a hospital-based discharge medication program implemented throughout an integrated multiple-hospital network. Ann Intern Med 2004;141:446-453.
17. Anderson JL, Allen Maycock CA, Lappé DL, Crandall BG, Horne BD, Bair TL, Li Q, Muhlestein JB. Frequency of elevation of C-reactive protein in atrial fibrillation. Am J Cardiol 2004;94:1255-1259.
18. Bunch TJ, Muhlestein JB, Bair TL, Renlund DG, Lappé DL , Jensen KR, Horne BD, Carter MA, Anderson JL. Effect of beta-blocker therapy on mortality rates and future myocardial infarction rates in patients with coronary artery disease but no history of myocardial infarction or congestive heart failure. Am J Cardiol 2005;95:827-831.
19. Anderson JL, Muhlestein JB, Bair TL, Morris S, Weaver AN, Lappé DL, Renlund DG, Pearson RR, Jensen KR, Horne BD. Do statins increase the risk of idiopathic polyneuropathy? Am J Cardiol 2005;95:1097-1099.
20. Jones HU, Muhlestein JB, Jones KW, Renlund DG, Bair TL, Bunch TJ, Horne BD, Lappé DL, Anderson JL, Doty DB. Early postoperative use of unfractionated heparin or enoxaparin is associated with increased surgical re-exploration for bleeding. Ann Thorac Surg 2005;80:518-522.